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What Causes Alopecia Universalis?

In alopecia universalis, immune system cells called white blood cells attack the rapidly growing cells in the hair follicles that make the hair. The affected hair follicles become small and drastically slow down hair production. Fortunately, the stem cells that continually supply the follicle with new cells do not seem to be targeted. So the follicle always has the potential to regrow hair.

Scientists do not know exactly why the hair follicles undergo these changes, but they suspect that a combination of genes may predispose some people to the disease. In those who are genetically predisposed, some type of trigger–perhaps a virus or something in the person’s environment–brings on the attack against the hair follicles.

There are, however, studies that have been done that show a genetic link for those people who are diagnosed as having Alopecia Universalis. According to MedicineNet.com, the “disorder is inherited as an autosomal recessive trait. It is caused by a mutation in a gene dubbed HR in chromosome band 8p21.2 that is the human homolog of the mouse “hairless” gene — the human version of the gene in the mouse that is responsible for hairless mice.” Huh?? Basically they are saying that a good majority of those who develop alopecia universalis have a hereditary gene that could be the possible cause of their hair loss. This is great news since pinpointing a gene may provide scientists a more targeted approach to treating hair growth disorders such as alopecia.

More information concerning studies such as this can be found at: